Adenosine and extracellular volume in radiocontrast media-induced nephropathy
نویسندگان
چکیده
منابع مشابه
Radiocontrast induced nephropathy.
In spite of improvements in chemical structure, contrast media assisted X-ray examination is still the third leading cause of hospital-acquired acute renal failure. An increase >50% or >88 micro mol/L in S-creatinine is a clinically important acute renal failure. The peak in S-creatinine occurs within 2-5 days after exposure. The frequency of oliguria, transient or permanent haemodialysis is un...
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Despite recent medical progress in supportive medical absent, DM present (n=318); (iii) RI present, DM absent (n=298); (iv) both RI and DM present (n=216) therapy, the frequency of hospital-acquired acute renal failure has increased in recent years from ~5% to [14]. The frequency of RCIN, defined as an increase of serum creatinine 0.5 mg/dl, was 8.5% for iohexol (I ) 6.4% [1,2]. Even more distr...
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To evaluate therapeutic options for the prevention of radiocontrast media (RCM)-induced nephropathy, a model was developed in which rats received NG-nitro-L-arginine methyl ester (L-NAME) for 10 wk in order to inhibit nitric oxide (NO) synthetase. This study tests the hypothesis that infusion of an adenosine antagonist before RCM application may avoid the vasoconstrictive response in NO-deplete...
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Radiocontrast nephropathy (RCN) is a common clinical problem for which there is no effective therapy. Utilizing a murine model, we tested the hypothesis that alpha(2)-adrenergic receptor agonists (clonidine and dexmedetomidine) protect against RCN induced with iohexol (a nonionic low-osmolar radiocontrast). C57BL/6 mice were pretreated with saline, clonidine, or dexmedetomidine before induction...
متن کاملN-acetylcysteine in the prevention of radiocontrast-induced nephropathy.
N-acetylcysteine is a remarkably active agent shown to be useful in a variety of clinical settings. The drug has actions relevant to radiocontrast-induced nephropathy (RCIN) that include vasodilatation, enhancement of renal medullary blood flow, and antioxidant properties. The drug's pharmacokinetics are remarkable for almost complete first pass metabolism after oral administration, resulting i...
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ژورنال
عنوان ژورنال: Kidney International
سال: 1998
ISSN: 0085-2538
DOI: 10.1046/j.1523-1755.1998.06744.x